Conversely, liver conditions like metabolic dysfunction-associated steatotic liver disease (MASLD), also known as non-alcoholic fatty liver disease (NAFLD) can increase the risk of HF due to systemic inflammation, oxidative stress, and metabolic disturbances [34, 35]
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63,64,65,66,67 Because RNase H is active in the nucleus and cytoplasm, ASOs can also target other transcripts, such as long non-coding RNAs
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